Mitochondrial Dysfunction and Metabolic Regulation in Brain Health
Mitochondria are essential for neuronal energy production, calcium homeostasis, and regulation of oxidative stress. Dysfunction in mitochondrial pathways contributes to neurodegenerative diseases, cognitive decline, and metabolic brain disorders. Research advances highlight the impact of impaired oxidative phosphorylation, increased reactive oxygen species, and disrupted metabolic signaling on neuronal survival. Emerging studies explore metabolic therapies, antioxidant strategies, and mitochondrial-targeted compounds aimed at restoring cellular energy balance. Advanced metabolomics and imaging technologies enable precise assessment of brain energy dynamics. Understanding the interplay between metabolic health and neural function opens new avenues for preventive and therapeutic interventions. Targeting mitochondrial pathways represents a promising strategy for maintaining brain resilience and delaying neurodegenerative progression.