Neuropathic Pain & Neuropathology

Neuropathic Pain:

Chronic pain related with tissue injury is termed as Neuropathic pain. Neurosurgery plays an enormous impact on such neuropathic pain. The impact of nerve fibre injury includes a change in nerve function both at the location of injury and areas round the injury. Nerve pressure or nerve damage after surgery or trauma alongside viral infections, cancer, and even vascular malformations, alcoholism, neurological conditions like MS and metabolic conditions such as diabetes are the common explanation for neuropathic pain. Peripheral neuropathic pain, central neuropathic pain, or mixed (peripheral and central) neuropathic pains are the three basic mechanism of neuropathic pain.

Statistics says that 7- 8% of the Europe population is affected, out of which 5% of patients are severely traumatized. Anti-epileptics, Antidepressants, Opioids, Transcutaneous electrical nerve stimulation (TENS) and percutaneous electrical nerve stimulation (PENS) are the few treatment processes for neuropathic pain.

Neuropathology:

Neuropathology consists largely of examination of biopsy tissue from the brain and medulla spinalis to assist in diagnosis of disease. It is an important aspect for neurosurgery. The subject often confused with neuropathy deals with laboratory analysis of tissue samples for personalized diagnosis or forensic investigations.

Neurological disorder pathogenesis including related neuronal and glial pathology, the Golgi body, RNA-mediated regulation of organic phenomenon, RNA stability, RNA splicing, signal transduction, and therefore the cytoskeleton may come under the part of neuropathology. Research subjects on neurology like developmental neurobiology, developmental neuropathology and biology of paediatric and adult brain tumours are recent additional.

 

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