Neurotoxicology & Environment

Neurotoxicology is the study of how environmental toxins and chemicals affect the nervous system, leading to cognitive, behavioral, and motor impairments. The brain and nervous system are highly sensitive to toxic substances, which can interfere with neuronal function, disrupt neurotransmitter signaling, and cause long-term damage. Exposure to neurotoxic agents can occur through air, water, food, and occupational settings, contributing to the development of neurodegenerative diseases, developmental disorders, and mental health conditions. Common environmental neurotoxins include heavy metals (lead, mercury, arsenic), pesticides, industrial chemicals (polychlorinated biphenyls, dioxins), air pollutants, and certain pharmaceuticals. Heavy metal exposure, especially during early brain development, has been linked to cognitive deficits, reduced IQ, and neurodevelopmental disorders such as autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD). Pesticides and herbicides, such as organophosphates, have been associated with Parkinson’s disease and neurodegenerative decline due to their ability to induce oxidative stress and mitochondrial dysfunction.

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